2026年6月 論文掲載

Glycine removal from both glycinergic and glutamatergic synapses into
astrocytic processes by glycine transporter 1 in the adult mouse spinal cord

Chigusa Shimizu-Okabe, Ryuki Kobayashi, Toshihiro Konno, Yoshihisa Ishihara,

Chitoshi Takayama

Neuroscience Letters

https://pubmed.ncbi.nlm.nih.gov/42252052/

2025年8月 論文掲載

TRPV1 antagonist AMG9810 suppresses focal epileptiform discharges and seizures by decreasing extracellular glutamate concentrations in mice

Hiroshi Moriyama, Hirochika Imoto, Sadahiro Nomura, Naomasa Mori, Yuichi Maruta, Natsumi Fujii, Shunsuke Fujitsuku, Hideyuki Ishihara

J Pharmacol Sci. 2025 Nov;159(3):163-171.
doi: 10.1016/j.jphs.2025.08.007.

2025年7月 論文掲載

Acceleration of axonal regeneration by GABA/Gly excitation
Chitoshi Takayama,  Tsukasa Yafuso

Anatomical Science International

https://link.springer.com/article/10.1007/s12565-025-00869-8

2025年6月 論文掲載

Anti-seizure effects of WS-3, a TRPM8 agonist, on focal onset seizure mouse model via reduction of extracellular glutamate levels

Hiroshi Moriyama, Sadahiro Nomura, Hirochika Imoto, Yuichi Maruta, Naomasa Mori, Natsumi Fujii, Kohei Haji, Michiyasu Suzuki, Hideyuki Ishihara

Neuropsychopharmacology. 2025 Nov;50(12):1855-1863.

doi: 10.1038/s41386-025-02143-x.

2024年12月 論文掲載

Number of subfields of the rat dorsal subiculum defined by NOS and PCP4 immunoreactivity changes according to different levels of observation

Yoshihisa Ishihara, Fumi Sato, Alix Guinet , Sabine Grosser, Imre Vida, Yoshiyuki Kubota, Chitoshi Takayama

Neuroscience

https://pubmed.ncbi.nlm.nih.gov/39755232/

2024年10月 論文投稿

Structural diversity inside the mouse subiculum revealed by a new marker protein fibronectin 1.

Yoshihisa Ishihara, Yuta Miyamoto, Shigeyuki Esumi, Takaichi Fukuda

Anatomical science international

https://pubmed.ncbi.nlm.nih.gov/39365413/

2024年5月 論文掲載

Reduced gene expression of KCC2 accelerates axonal regeneration and reduces motor dysfunctions after tibial nerve severance and suturing
Hironobu Ando, Chigusa Shimizu-Okabe, Nobuhiko Okura, Tsukasa Yafuso, Yoshinori Kosaka, Shiori Kobayashi, Akihito Okabe and Chitoshi Takayama

Neuroscience
https://www.sciencedirect.com/science/article/abs/pii/S0306452224002124

2022年2月 論文掲載

Specific expression of KCC2 in the α cells of normal and type 1 diabetes model mouse pancreatic islets

Chigusa Shimizu-Okabe, Shigeki Okada1, Shiki Okamoto, Hiroaki Masuzaki and Chitoshi Takayama

Acta Histochem. Cytochem. 55 (1): 47–56, 2022

https://www.jstage.jst.go.jp/article/ahc/55/1/55_21-00078/_html/-char/ja

この論文は、「医科学研究(2019)」期間中に、岡田滋喜さんが行った実験結果が中心になっています。

http://molanatomy.blogspot.com/2020/04/2019m3.html

さらに、医学科学生の片岡あかりさん、比嘉奈津貴さんも、この論文の作成にあたって、協力してくれました。

2022年1月 論文掲載

Developmental Formation of the GABAergic and Glycinergic Networks in the Mouse Spinal Cord

Chigusa Shimizu-Okabe, Shiori Kobayashi, Jeongtae Kim, Yoshinori Kosaka, Masanobu Sunagawa, Akihito Okabe and Chitoshi Takayama

International Journal of Molecular Science (Open Access)

https://www.mdpi.com/1422-0067/23/2/834

2021年10月 論文掲載

Slow progression of sciatic nerve degeneration and regeneration after loose ligation through microglial activation and decreased KCC2 levels in the mouse spinal cord ventral horn

Tsukasa Yafuso, Yoshinori Kosaka, Chigusa Shimizu-Okabe, Nobuhiko Okura, Shiori Kobayashi, Jeongtae Kim, Koyata Matsuda, Daichi Kinjo, Akihito Okabe, Chitoshi Takayama

Neuroscience Research

https://www.sciencedirect.com/science/article/pii/S0168010221002170?via%3Dihub

なお、この研究では、クリニカルクラークシップで実習した金城大智さんと、医科学研究で参加した松田小弥太さんの二人が有髄線維の定量的解析法の開発で大きな貢献をしてくれました。

クリニカル クラークシップ 講座発表会の様子（2019年7月HP掲載）

http://molanatomy.blogspot.com/2019/07/201971-26m6.html

2019年度 医科学研究 発表ポスターと学生（2020年4月HP掲載）

http://molanatomy.blogspot.com/2020/04/2019m3.html

2021年6月 論文掲載

Factors Affecting Neurodevelopment 

Genetics, Neurology, Behavior, and Diet

Part Ⅱ

Chapter 24

「Development of the GABAergic network in the mouse spinal cord」
Shiori Kobayashi, Chigusa Shimizu-Okabe, Jeongtae Kim, Yoshinori Kosaka, Masanobu Sunagawa, Akihito Okabe, and Chitoshi Takayama

https://www.sciencedirect.com/science/article/pii/B9780128179864000249
　

2020年2月7日 論文掲載

Development and persistence of neuropathic pain through microglial activation and KCC2 decreasing after mouse tibial nerve injury

Yoshinori Kosaka, Tsukasa Yafuso, Chigusa Shimizu-Okabe, Jeongtae Kim, Shiori Kobayashi, Nobuhiko Okura, Hironobu Ando, Akihito Okabe, Chitoshi Takayama

https://www.sciencedirect.com/science/article/pii/S0006899320300743?via%3Dihub

2019年12月14日 論文掲載

Hyper-formation of GABA and glycine co-releasing terminals in the mouse cerebellar nuclei after deprivation of GABAergic inputs from Purkinje cells

Shiori Kobayashi, Jeongtae Kim, Yuchio Yanagawa, Noboru Suzuki, Hiromitsu Saito, Chitoshi Takayama

https://www.sciencedirect.com/science/article/pii/S0306452219308139?via%3Dihub

論文のFigureが『Neuroscience誌 2月号』の表紙に採用されました

論文掲載

2016年度の「医科学研究」にて当時3年生の上原里依さんが3か月間ドイツに短期留学して研究した成果が、本学術論文の一部として科学雑誌に受理されました。

Allopregnanolone augments epileptiform activity of an in-vitro mouse hippocampal preparation in the first postnatal week
Salim Sharopov,, Paula Winkler, Rie Uehara, Aniello Lombardi, Lisa Halbhuber, Akihito Okabe, Heiko J. Luhmanna, Werner Kilb

Epilepsy Research

Volume 157, November 2019

https://doi.org/10.1016/j.eplepsyres.2019.106196

ドイツの研究室メンバー（2017.3）

論文掲載

マウス坐骨神経損傷モデルにおけるGABAシグナル関連分子の発現変化
GABAergic signaling during degeneration and regeneration of mouse sciatic nerve

 Tsukasa Yafuso, Yoshinori Kosaka, Shiori Kobayashi, Jeongtae Kim, Chigusa Shimizu, Akihito Okabe, Chitoshi Takayama.

2017 理学療法沖縄 VOL.19 　2018年3月31日発行

2017年11月22日 論文掲載

Embryonic development of GABAergic terminals in the mouse hypothalamic nuclei involved in feeding behavior
Masato Kobayashi, Chigusa Shimizu-Okabe, Jeongtae Kim, Shiori Kobayashi, Masayuki Matsushita, Hiroaki Masuzaki, Chitoshi Takayama
Neuroscience Research

http://www.sciencedirect.com/science/article/pii/S0168010217303139

2017年11月4日 論文掲載

Changes in the expression and localization of signaling molecules in mouse facial motor neurons during regeneration of facial nerves
Jeongtae Kim, Shiori Kobayashi, Chigusa Shimizu-Okabe, Akihito Okabe, Changjong Moon, Taekyun Shin, Chitoshi Takayama
Journal of Chemical Neuroanatomy 88(2018)13-21

https://authors.elsevier.com/a/1W0Fy3Acf-5zST

2016年12月28日 論文掲載

Distinct development of the glycinergic terminals in the ventral and dorsal horns of the mouse cervical spinal cord

Masanobu Sunagawa, Chigusa Shimizu-Okabe, Jeongtae Kim,Shiori Kobayashi, Yoshinori Kosaka, Yuchio Yanagawa,Masayuki Matsushita, Akihito Okabe,  Chitoshi Takayama

Neuroscience 343 (2017) 459 - 471

2016年5月27日 論文掲載

Hepatoprotective effects of allyl isothiocyanate against carbon tetrachloride-induced hepatotoxicity in rat.

Meejung Ahn, Jeongtae Kim, Hyojin Bang, Jihwan Moon, Gi Ok Kim, Taekyun Shin

Chemico-Biological Interactions 254 (2016) 102-108

2015年12月2日 論文掲載

Developmental and degenerative modulation of GABAergic transmission in the mouse hippocampus.
Kim J, Son Y, Kim J, Lee S, Kang S, Park K, Kim SH, Kim JC, Kim J, Takayama C, Im HI, Yang M, Shin T, Moon C.
Int J Dev Neurosci. 2015 Sep 21. pii: S0736-5748(15)30048-4. doi: 10.1016/j.ijdevneu.2015.08.009. [Epub ahead of print]

http://www.ncbi.nlm.nih.gov/pubmed/?term=developmental+and+degenerative+modulation+of+GABAergic